Associate Scientist/Scientist in Protein Science
Title: Associate Scientist/Scientist
Location: Bay Area (On-site)
Keywords: Protein Science, Protein Engineering
General Summary
We are seeking a skilled scientist in Associate Scientist to Scientist level with a background in Protein Science and Structural Biology in the Bioengineering Department at BioMap. This position will mainly focus on recombinant protein/enzyme production and characterization, computation-aided library generation, high-throughput screening, and structural biology.
We are a multi-disciplinary team working closely with computational scientists on mini-binders, nanobodies, antibodies, and enzymes, supporting the discovery of bio-therapeutics through our engineering expertise. The successful candidate has a background within protein science and structural biology, and preferably experience with membrane protein production, protein characterization and HT display methodologies.
This is a wonderful opportunity to work with world-class biologists, AI/ML scientists, and engineers to explore the next-generation therapeutical drug development.
Job Responsibilities
· Generate high quality antigens for protein engineering campaigns in various host cells, with focus on the HEK and CHO cell systems.
· Work closely with other scientists on protein/enzyme engineering projects by using display technologies, NGS, flow cytometry, liquid handler, microplate reading, etc.
· Help design the DNA constructs, and generate the synthetic DNA library by molecular biology techniques, including RT-PCR, gene cloning, mammalian cell transfection, etc.
· Analyze libraries by FACS sorting and NGS to screen for lead candidates.
· Assist the HTP protein/enzyme characterization and in vitro/in vivo assay development.
· Collaborate with cross-functional teams for project development.
· Routine laboratory instruments maintenance, including mammalian cell cultures, AKTA, HPLC, etc.
· Demonstrate ability to combine, analyze, and visualize data from multiple sources.
· Attend internal and external meeting to represent the department or company for project presentation.
Qualifications
· A Master’s or a Ph.D’s degree within subject matter expertise are preferred.
· Recombinant protein and enzyme production in mammalian or insect cells, experience on protein purification system (such as AKTA) and protein characterization (SPR/BLI, functional validation).
· Experience with membrane protein generation (preferring nanodiscs format).
· Good understanding of antibody and enzyme science
· Experience with different protein formats, such as antibody, nanobody, mini-binder, and enzyme.
· Experience with cell-based compound characterization, microscopy, mammalian cell display technologies, Flow cytometry, NGS is a plus.
· Experience with therapeutic drug development is a plus.
· Familiar with industrial working standards, including LIMS.
· Demonstrates excellent verbal and written communication skills.
· Good working attitude in a fast-growing organization.
Applications
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